Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice
Rachel Cantrell, H. Alex Feldman, Leah A. Rosenfeldt, Ayad Ali, Benjamin Gourley, Cassandra Sprague, Daniel G. Leino, Jeff R. Crosby, Alexey S. Revenko, Brett P. Monia, Stephen N. Waggoner, Joseph S. Palumbo
This study shows that prothrombin prevents fatal T cell-dependent anemia in mice during chronic viral infection by reducing hemolysis, not by affecting T cell function or viral load.
JCI Insight · Jan 16, 2025Peer-reviewedImmunology