Author

Elena Vialetto

Helmholtz Centre for Infection ResearchORCID 0000-0002-7474-4710Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Organism:E. coli· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Chase L. BeiseliD· 2 shared Ann-Sophie RüttigeriD· 1 shared Daphne ColliasiD· 1 shared Éva d. H. AlmásiiD· 1 shared Jiaqi YuiD· 1 shared Katharina G. WanderaiD· 1 shared Khoa Co· 1 shared Lars BarquistiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSynthetic Biology

Chase L. BeiselORCID

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2 papers

Recent·Most cited

Synthetic BiologyNature CommunicationsPeer-reviewedFeb 8, 2023

Systematically attenuating DNA targeting enables CRISPR-driven editing in bacteria

Daphne Collias, Elena Vialetto, Jiaqi Yu…·Chase L. Beisel

This paper shows that reducing DNA targeting activity in CRISPR systems improves genome editing efficiency in bacteria by enabling RecA-mediated repair.

40 citations

E. colimouse

Molecular BiologybioRxivPreprintNov 23, 2021

A target expression threshold dictates invader defense and autoimmunity by CRISPR-Cas13

Elena Vialetto, Yanying Yu, Scott P. Collins…·Chase L. Beisel

The paper shows that CRISPR-Cas13 systems require target transcript expression above a threshold to induce dormancy, distinguishing pathogenic from benign invaders and preventing autoimmunity.

3 citations

CRISPR screenexperimental assay