Yanying Yu

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

This study shows the SARS-CoV-2 nucleocapsid protein drives hyperinflammation and vascular leakage in macrophages via Toll-like receptor signaling, contributing to severe COVID-19 complications.

RNA Quality Control Enables Antibiotic Tolerance

This study shows that RNA quality control through rny mutations enables antibiotic tolerance in Streptococcus pneumoniae by balancing transcriptional resilience and degradation.

Biased sampling confounds machine learning prediction of antimicrobial resistance

This study shows that biased sampling in bacterial genome data leads to poor performance in machine learning models predicting antimicrobial resistance.

A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria

IMPRINT uses cell-free transcription-translation to methylate DNA, bypassing bacterial restriction and improving transformation efficiency in diverse bacteria.

Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect modeling and data integration

The paper develops a mixed-effect random forest model to predict CRISPRi guide efficiency using data from depletion screens and gene-specific features, outperforming existing methods.

A target expression threshold dictates invader defense and autoimmunity by CRISPR-Cas13

The paper shows that CRISPR-Cas13 systems require target transcript expression above a threshold to induce dormancy, distinguishing pathogenic from benign invaders and preventing autoimmunity.