Author

Katharina G. Wandera

Helmholtz Centre for Infection ResearchORCID 0000-0002-5660-591XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Chase L. BeiseliD· 2 shared Angela MiguriD· 1 shared Anuja KibeiD· 1 shared Elena VialettoiD· 1 shared Lars BarquistiD· 1 shared Neva CaliskaniD· 1 shared Peer LukatiD· 1 shared Scott P. CollinsiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Chase L. BeiselORCID

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2 papers

Recent·Most cited

AcrVIB1 inhibits CRISPR-Cas13b immunity by promoting unproductive crRNA binding accessible to RNase attack

Katharina G. Wandera, Stefan Schmelz, Angela Migur, Anuja Kibe, Peer Lukat, Tatjana Achmedov, Neva Caliskan, Wulf Blankenfeldt, Chase L. Beisel

This paper shows AcrVIB1 inhibits CRISPR-Cas13b by promoting unproductive crRNA binding and degradation, revealing a mechanism to suppress immune defense.

Molecular Cell · Feb 17, 2025Peer-reviewedBiochemistry

A target expression threshold dictates invader defense and autoimmunity by CRISPR-Cas13

Elena Vialetto, Yanying Yu, Scott P. Collins, Katharina G. Wandera, Lars Barquist, Chase L. Beisel

The paper shows that CRISPR-Cas13 systems require target transcript expression above a threshold to induce dormancy, distinguishing pathogenic from benign invaders and preventing autoimmunity.

bioRxiv · Nov 23, 2021 · PreprintMolecular Biology