Scott P. Collins

This paper introduces append editing, a method that uses ADP-ribosylation to achieve distinct genome editing outcomes in bacteria and eukaryotes.

The paper shows that CRISPR-Cas13 systems require target transcript expression above a threshold to induce dormancy, distinguishing pathogenic from benign invaders and preventing autoimmunity.

This paper characterizes genetic elements in Saccharomyces boulardii to enable engineered biomolecule synthesis and delivery in the gut, showing tunable gene expression and colonization dynamics.

This paper introduces an E. coli cell-free system to rapidly and scalably characterize CRISPR technologies, including DNA cleavage, gene repression, and anti-CRISPR activity.