Author

Natalie J. Kirkland

Altos LabsORCID 0000-0002-7479-1883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Assay:ATAC-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Manuel A CastroiD· 2 shared Pura Muñoz‐CánovesiD· 2 shared Yanlan MaoiD· 2 shared Yihao YangiD· 2 shared Zachary A. LevineiD· 2 shared Adam Jeffrey EngleriD· 1 shared Alexandre R. ColasiD· 1 shared Alice C. YueniD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

Manuel A CastroORCID

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5 papers

Recent·Most cited

Cell BiologyJournal of Cell SciencePeer-reviewedOct 30, 2026

Visualizing the Epigenetic Landscape of Aging and Cellular Reprogramming: Optimized ATAC-see for Cells and Tissues

Natalie J. Kirkland, Manuel Castro, Yihao Yang…·Zachary A. Levine

The paper optimizes ATAC-see for high-throughput chromatin accessibility imaging in aging and reprogramming, revealing age-related chromatin changes and reprogramming-induced remodeling.

2 citations

humanmouse

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Cell BiologyJournal of Cell SciencePeer-reviewedAug 27, 2026

Targeted ATAC-see (tATAC-see): A Visual Assay for Target-Specific Chromatin Profiling

Natalie J. Kirkland, Yihao Yang, Manuel A Castro…·Zachary A. Levine

tATAC-see captures target-specific chromatin states using a visual assay, showing dynamic remodeling in aging models and LAD resistance.

1 citation

humanATAC-seq

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Genetic & Genomic MedicineeLifePeer-reviewedJul 5, 2023

Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity

Katja Birker, Shuchao Ge, Natalie J. Kirkland…·Rolf Bodmer

The paper identifies mitochondrial MICOS complex genes, CHCHD3 and CHCHD6, as contributors to hypoplastic left heart syndrome through functional studies in Drosophila and genetic analysis of patient cohorts.

20 citations

Drosophilawhole-genome sequencing

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Developmental BiologyCurrent BiologyPeer-reviewedMay 14, 2020

Tissue mechanics regulate mitotic nuclear dynamics during epithelial development

Natalie J. Kirkland, Alice C. Yuen, Melda Tozluoǧlu…·Yanlan Mao

The paper shows that tissue mechanics influence mitotic nuclear migration in Drosophila wing disc epithelia, with Rho kinase and Diaphanous playing key roles in nuclear positioning under varying cell density.

32 citations

Drosophilaexperimental assay

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BiophysicsbioRxivPreprintJan 9, 2019

Planar differential growth rates determine the position of folds in complex epithelia

Melda Tozluo◻lu, Maria Duda, Natalie J. Kirkland…·Yanlan Mao

The paper models how planar differential growth rates determine fold positions in Drosophila wing imaginal discs.

DOI 10.1101/515528

Drosophilamechanistic / dynamical model

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