Zachary A. Levine

The paper optimizes ATAC-see for high-throughput chromatin accessibility imaging in aging and reprogramming, revealing age-related chromatin changes and reprogramming-induced remodeling.

The paper develops a multiscale model to study how conformational dynamics regulate the PP1-GADD34-eIF2 complex, showing folding-dependent assembly enhances biochemical function.

tATAC-see captures target-specific chromatin states using a visual assay, showing dynamic remodeling in aging models and LAD resistance.

This study designs and evaluates LDLR-LA peptides to inhibit ApoE4 endocytosis, showing isoform-dependent uptake dynamics and identifying LA345 as the most stable construct.

This study shows that ApoE lipidation, not isoform, most strongly affects Aβ interaction, uptake, and cytotoxicity in astrocytes.

This study investigates whether consensus DNA sequences can regulate p53 aggregation in wild-type and mutant forms, finding that while consensus DNA inhibits wild-type p53 aggregation, oncogenic mutants evade this regulation and may even enhance aggregation.

This study uses molecular dynamics simulations to investigate how binders of disordered proteins select between different conformations, showing that conformational selection can override sequence specificity in some cases.