Elena Kuzmin

Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer

This study maps the metabolic complex genetic interaction network of chromosome 4p loss in basal breast cancer to identify targetable vulnerabilities.

PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database

PARPAL is a web database that analyzes protein redistribution in yeast after paralog deletion using high-content screening and deep learning, providing insights into gene retention and evolution.

Benchmarking macaque brain gene expression for horizontal and vertical translation

This study benchmarks macaque brain gene expression for horizontal and vertical translation by comparing it to human gene expression and protein density.

Evolution of chromosome arm aberrations in breast cancer through genetic network rewiring

The paper investigates the evolution of chromosome 4p loss in basal breast cancer, identifying C4orf19 as a novel gene that suppresses proliferation and is part of a kinase module.

Single-cell imaging of protein dynamics of paralogs reveals mechanisms of gene retention

This study uses single-cell imaging to analyze protein dynamics in response to paralog deletion, revealing mechanisms of gene retention and functional divergence.

Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

The paper examines the relationship between gene expression and neurotransmitter receptor/transporter density in the human brain using PET and autoradiography, finding poor spatial correspondence except for four specific receptors.