Author

Brittany M. Greco

Concordia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:protein structure prediction· 2 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aashiq Hussain KachrooiD· 2 shared Elena KuzminiD· 2 shared Leopold PartsiD· 2 shared Mikhail PapkoviD· 2 shared Rohan DandageiD· 2 shared Benjamin Grys· 1 shared Brenda AndrewsiD· 1 shared Charles M. BooneiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenetics

Aashiq Hussain KachrooORCID

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4 papers

Recent·Most cited

PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database

Brittany M. Greco, Gerardo A. Zapata, Rohan Dandage, Mikhail Papkov, Vanessa Pereira, François Lefebvre, Guillaume Bourque, Leopold Parts, Elena Kuzmin

PARPAL is a web database that analyzes protein redistribution in yeast after paralog deletion using high-content screening and deep learning, providing insights into gene retention and evolution.

G3 Genes Genomes Genetics · Jun 28, 2025Peer-reviewedSystems Biology

A humanized yeast model for studying TRAPP complex mutations; proof-of-concept using variants from an individual with a TRAPPC1-associated neurodevelopmental syndrome

Erta Zykaj, Chelsea Abboud, Paria Asadi, Simane Warsame, Hashem A Almousa, Miroslav P. Milev, Brittany M. Greco, Marcos López‐Sánchez, Drago Bratkovic, Aashiq Hussain Kachroo, Luis Alberto Pérez Jurado, Michael G. Sacher

This study develops a humanized yeast model to study TRAPP complex mutations, showing that human TRAPPC1 variants cause secretion and autophagy defects in yeast, mirroring human fibroblast defects.

Cells · Aug 30, 2024Peer-reviewedGenetics

Single-cell imaging of protein dynamics of paralogs reveals mechanisms of gene retention

Rohan Dandage, Mikhail Papkov, Brittany M. Greco, Dmytro Fishman, Helena Friesen, Kyle E. Wang, Erin B. Styles, Oren Z. Kraus, Benjamin Grys, Charles M. Boone, Brenda Andrews, Leopold Parts, Elena Kuzmin

This study uses single-cell imaging to analyze protein dynamics in response to paralog deletion, revealing mechanisms of gene retention and functional divergence.

bioRxiv · Nov 23, 2023 · PreprintSystems Biology

Rapid, scalable, combinatorial genome engineering by Marker-less Enrichment and Recombination of Genetically Engineered loci (MERGE)

Mudabir Abdullah, Brittany M. Greco, Jon M. Laurent, Michelle Vandeloo, Edward M. Marcotte, Aashiq Hussain Kachroo

The paper introduces MERGE, a method for marker-less, scalable genome editing in yeast by combining CRISPR-Cas9 and gene drives to efficiently integrate and combine multiple genetic edits.

bioRxiv · Jun 17, 2022 · PreprintSynthetic Biology