Kyle E. Wang

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

The paper identifies PRC2.1's role in opposing G1 progression by regulating CCND1 and CCND2, showing its importance in cell proliferation across multiple cancer types.

PIFiA is a self-supervised method for protein functional annotation from single-cell imaging data, outperforming existing approaches and enabling downstream analysis of protein organization.

This study uses single-cell imaging to analyze protein dynamics in response to paralog deletion, revealing mechanisms of gene retention and functional divergence.