This study develops a genetics-informed framework to repurpose drugs for type 2 diabetes, identifying telmisartan as a potential treatment based on GWAS data and EHR validation.

medRxiv · Mar 22, 2025 · PreprintGenetic & Genomic Medicine

CD40 ligation-induced ERK activation promotes autophagy which leads to enhanced radiosensitivity in cervical carcinoma cells

Baocai Liu, Yadong Zhang, Quan Wang, Qian Wang, Zhixin Wang, Li Feng

This study shows CD40 ligation increases autophagy via ERK-mediated ATG13 upregulation, enhancing radiosensitivity in cervical cancer cells.

Acta Biochimica et Biophysica Sinica · Dec 8, 2024Peer-reviewedCell Biology

Integration of multidimensional splicing data and GWAS summary statistics for risk gene discovery

Ying Ji, Qiang Wei, Rui Chen, Quan Wang, Ran Tao, Bingshan Li

This paper introduces MSG, a method that integrates splicing data and GWAS summary statistics to identify trait-associated genes, showing improved power over existing methods.

PLoS Genetics · Jun 30, 2022Peer-reviewedGenetics

DRAMS: A Tool to Detect and Re-Align Mixed-up Samples for Integrative Studies of Multi-omics Data

Yi Wei Jiang, Gina M. Giase, Kay S. Grennan, Annie W. Shieh, Yan Xia, Lide Han, Quan Wang, Qiang Wei, Rui Chen, Sihan Liu, Kevin P. White, Chao Chen, Bingshan Li, Chunyu Liu

DRAMS detects and corrects sample mix-ups in multi-omics data by aligning genetic and omics data, improving statistical power and result quality.

PLoS Computational Biology · Apr 13, 2020Peer-reviewedBioinformatics