Lorna J. Daniels

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

The paper develops methods to detect glycophagy in cardiac cells using antibodies and fluorescent markers to measure lysosomal flux and glycogen accumulation.

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.