Roberta A. Gottlieb

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

The paper develops methods to detect glycophagy in cardiac cells using antibodies and fluorescent markers to measure lysosomal flux and glycogen accumulation.

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

This study shows that D2-HG induces cachexia in mice by disrupting NAD+ homeostasis and autophagy, revealing metabolic vulnerabilities in skeletal muscle.

MitoPlex is a targeted MS assay for quantifying 37 mitochondrial proteins, paired with a metabolite assay, showing statin effects on mitochondrial function in different tissues.

This study shows that cardiosphere-derived cells and their exosomes improve cardiac and skeletal muscle function in Duchenne muscular dystrophy models.