ImmunologybioRxivPreprint
Hypercholesterolaemia promotes epigenetic memory in hematopoietic stem cells that persists after lipid lowering and causes systemic immunometabolic dysfunction mediated by macrophage metabolic reprogramming
Gareth S. D. Purvis, Jiahao Jiang, Thomas K. Hiron…·Keith M. Channon
This study shows that high cholesterol induces epigenetic changes in hematopoietic stem cells that persist after cholesterol reduction, leading to systemic immunometabolic dysfunction.
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