Author

Stephen Adonai Leon‐Icaza

Centre National de la Recherche ScientifiqueORCID 0000-0002-7546-8228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:organoid / primary culture· 1 Organism:zebrafish· 1

Frequent Co-Authors

Céline CougouleiD· 2 shared António PeixotoiD· 1 shared Audrey BernutiD· 1 shared Carmen López‐IglesiasiD· 1 shared Célia BernardiD· 1 shared Charlotte BureauiD· 1 shared Christelle LangeviniD· 1 shared Christian ChalutiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Céline CougouleORCID

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2 papers

Recent·Most cited

ImmunologyBiomedicine & PharmacotherapyPeer-reviewedApr 2, 2025

Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis

Stephen Adonai Leon‐Icaza, Maxence Frétaud, Sarahdja Cornélie…·Audrey Bernut

This study shows curcumin improves inflammation and tissue damage in cystic fibrosis by restoring NRF2 activity in zebrafish and patient-derived airway organoids.

9 citationstop 4%

zebrafishorganoid / primary culture

Systems BiologyMolecular MicrobiologyPeer-reviewedOct 5, 2021

Mycobacteria-host interactions in human bronchiolar airway organoids

Nino Iakobachvili, Stephen Adonai Leon‐Icaza, Kèvin Knoops…·Peter J. Peters

This study uses human airway organoids to model tuberculosis infection, showing mycobacteria infect epithelial cells with low efficiency and the organoid microenvironment controls but does not eliminate the pathogen.

79 citationstop 5%

humanexperimental assay