NeurosciencebioRxivPreprint
Juxtacrine DLL4-NOTCH1 signaling between astrocytes drives neuroinflammation via the IL-6-STAT3 axis
Pierre Mora, Margaux Laisné, Célia Bourguignon…·Candice Chapouly
This study shows that DLL4-NOTCH1 signaling between astrocytes promotes neuroinflammation through the IL-6-STAT3 axis, and blocking DLL4 reduces experimental autoimmune encephalomyelitis symptoms.