Juxtacrine DLL4-NOTCH1 signaling between astrocytes drives neuroinflammation via the IL-6-STAT3 axis
Pierre Mora, Margaux Laisné, Célia Bourguignon, Paul Rouault, Alain‐Pierre Gadeau, Marie‐Ange Renault, Sam H. Horng, Thierry Couffinhal, Candice Chapouly
This study shows that DLL4-NOTCH1 signaling between astrocytes promotes neuroinflammation through the IL-6-STAT3 axis, and blocking DLL4 reduces experimental autoimmune encephalomyelitis symptoms.
bioRxiv · Oct 4, 2023 · PreprintNeuroscience