Candice Chapouly

This study shows that astrocyte CB1R signaling promotes inflammation in MS by disrupting the blood-brain barrier and reducing BBB function.

This study shows that DLL4-NOTCH1 signaling between astrocytes promotes neuroinflammation through the IL-6-STAT3 axis, and blocking DLL4 reduces experimental autoimmune encephalomyelitis symptoms.

This study shows that BBB disruption triggers a secondary barrier at the Glia Limitans via astrocytic response, reducing disease severity in multiple sclerosis.