Marie‐Ange Renault

This study identifies desert hedgehog (DHH) as a resilience factor that prevents atherosclerosis by inhibiting PAI-1 signaling and endothelial mesenchymal transition.

This study shows that DLL4-NOTCH1 signaling between astrocytes promotes neuroinflammation through the IL-6-STAT3 axis, and blocking DLL4 reduces experimental autoimmune encephalomyelitis symptoms.

This study identifies DHH as a key ligand in the Hedgehog signaling pathway that regulates fibro/adipogenic progenitor fate during skeletal muscle regeneration, preventing adipogenesis and promoting fibrosis.

This study shows that BBB disruption triggers a secondary barrier at the Glia Limitans via astrocytic response, reducing disease severity in multiple sclerosis.