Ultrasmall chemogenetic tags with group-transfer ligands
Vedagopuram Sreekanth, Shaimaa H. Sindi, Santosh Kumar Chaudhary, Rajaiah Pergu, Prashant Singh, Endri Karaj, Jeffrey E. Fung, Arghya Deb, Stephan J. DeCarlo, Jaron A. M. Mercer, Kei Yamada, Diego Rodriguez, David R. Liu, Amit Choudhary
The paper introduces two ultrasmall chemogenetic tags, mgTag and cTag, which enable group-transfer reactions to append moieties to proteins, demonstrating their utility in cell signaling and proximity induction.
bioRxiv · May 10, 2025 · PreprintSynthetic Biology