Author

Endri Karaj

Broad InstituteORCID 0000-0002-2393-9278Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Amit ChoudharyiD· 2 shared Jeffrey E. Fung· 2 shared Rajaiah PerguiD· 2 shared Santosh Kumar ChaudharyiD· 2 shared Shaimaa H. SindiiD· 2 shared Vedagopuram SreekanthiD· 2 shared Ananthan SadagopaniD· 1 shared April Keyes· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersSynthetic Biology

Amit ChoudharyORCID

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Author profile →

2 papers

Recent·Most cited

A Scalable Design for Proximity-Inducing Molecules

Endri Karaj, Varsha Venkatarangan, Shaimaa H. Sindi, Surached Siriwongsup, Chaiheon Lee, Rajaiah Pergu, Vedagopuram Sreekanth, Karishma Kailass, Kien Tran, Prashant Kumar Singh, Sameek Singh, Junya Kawai, Jeffrey E. Fung, Mahilet Tefera, Rohil Dhaliwal, , Amit Choudhary

This paper introduces GRIPs, a scalable platform for PTM editing using chimeric molecules, demonstrating functionality in multiple systems and confirming specificity through proteomics.

bioRxiv · Feb 21, 2026 · PreprintSynthetic Biology

Ultrasmall chemogenetic tags with group-transfer ligands

Vedagopuram Sreekanth, Shaimaa H. Sindi, Santosh Kumar Chaudhary, Rajaiah Pergu, Prashant Singh, Endri Karaj, Jeffrey E. Fung, Arghya Deb, Stephan J. DeCarlo, Jaron A. M. Mercer, Kei Yamada, Diego Rodriguez, David R. Liu, Amit Choudhary

The paper introduces two ultrasmall chemogenetic tags, mgTag and cTag, which enable group-transfer reactions to append moieties to proteins, demonstrating their utility in cell signaling and proximity induction.

bioRxiv · May 10, 2025 · PreprintSynthetic Biology