Author

Christopher A. Sumner

Sandia National Laboratories CaliforniaORCID 0000-0002-7572-4615Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jennifer L. SchwedleriD· 2 shared Anupama SinhaiD· 1 shared Ashlee M. PhillipsiD· 1 shared Brooke HarmoniD· 1 shared Daniel M. Gelperin· 1 shared Daniella V. MartineziD· 1 shared Dina R. WeilhammeriD· 1 shared Ethan P. DunniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Jennifer L. SchwedlerORCID

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2 papers

Recent·Most cited

Intracellular screening of nanobodies reveals an intrabody that inhibits ITCH E3 ubiquitin ligase

Jeffrey W.T. Wang, Victor L. Lam, Ethan P. Dunn, Salvador Martinez, Rachel A. Jones, Anupama Sinha, Joshua T. Hong, Raga Krishnakumar, Joseph S. Schoeniger, Jennifer L. Schwedler, Christopher A. Sumner, Oscar A Negrete, Steven S. Branda

The paper screens nanobodies to find an intrabody that inhibits ITCH E3 ubiquitin ligase activity in human cells using in vitro and intracellular assays.

bioRxiv · Aug 10, 2026 · PreprintCell Biology

Combining computational modeling and experimental library screening to affinity-mature VEEV-neutralizing antibody F5

Christopher A. Sumner, Jennifer L. Schwedler, Katherine Maia McCoy, J. E. Holland, Valerie Duva, Daniel M. Gelperin, Valeria Busygina, Maxwell A. Stefan, Daniella V. Martinez, Miranda A. Juarros, Ashlee M. Phillips, Dina R. Weilhammer, Gevorg Grigoryan, Michael S. Kent, Brooke Harmon

This paper combines computational modeling and experimental screening to enhance the affinity of the VEEV-neutralizing antibody F5, resulting in variants with significantly improved binding.

Protein Science · Jan 22, 2025Peer-reviewedMicrobiology