Combining computational modeling and experimental library screening to affinity-mature VEEV-neutralizing antibody F5
Christopher A. Sumner, Jennifer L. Schwedler, Katherine Maia McCoy, J. E. Holland, Valerie Duva, Daniel M. Gelperin, Valeria Busygina, Maxwell A. Stefan, Daniella V. Martinez, Miranda A. Juarros, Ashlee M. Phillips, Dina R. Weilhammer, Gevorg Grigoryan, Michael S. Kent, Brooke Harmon
This paper combines computational modeling and experimental screening to enhance the affinity of the VEEV-neutralizing antibody F5, resulting in variants with significantly improved binding.
Protein Science · Jan 22, 2025Peer-reviewedMicrobiology