Author

Ashlee M. Phillips

Lawrence Livermore National LaboratoryORCID 0000-0002-5494-7916Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Dina R. WeilhammeriD· 4 shared Margarita V. RangeliD· 3 shared Aimy SebastianiD· 2 shared Deepa K. MurugeshiD· 2 shared Nicholas R. HumiD· 2 shared Nicole F. LeoniD· 2 shared Nicole M. ColletteiD· 2 shared Adam P ArkiniD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

Dina R. WeilhammerORCID

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Author profile →

5 papers

Recent·Most cited

A Selenium-Deficient Mouse Model of Mouse-Adapted SARS-CoV-2 Demonstrates Variant Emergence Observed in SARS-CoV-2 Pandemic Variants

Monica E. Graham, Olukunle Oluwapamilerin Oluwasemowo, Deepa K. Murugesh, Margarita V. Rangel, Jeffrey A. Kimbrel, Aram Avila-Herrera, James B. Thissen, Adam T Zemla, Ashlee M. Phillips, Nicole M. Collette, Dina R. Weilhammer, Monica K. Borucki

This study shows selenium deficiency in mice increases viral mutation diversity and generates mutations seen in SARS-CoV-2 pandemic variants.

bioRxiv · Aug 26, 2026 · PreprintMicrobiology

Combining computational modeling and experimental library screening to affinity-mature VEEV-neutralizing antibody F5

Christopher A. Sumner, Jennifer L. Schwedler, Katherine Maia McCoy, J. E. Holland, Valerie Duva, Daniel M. Gelperin, Valeria Busygina, Maxwell A. Stefan, Daniella V. Martinez, Miranda A. Juarros, Ashlee M. Phillips, Dina R. Weilhammer, Gevorg Grigoryan, Michael S. Kent, Brooke Harmon

This paper combines computational modeling and experimental screening to enhance the affinity of the VEEV-neutralizing antibody F5, resulting in variants with significantly improved binding.

Protein Science · Jan 22, 2025Peer-reviewedMicrobiology

Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infection

Margarita V. Rangel, Aimy Sebastian, Nicole F. Leon, Ashlee M. Phillips, Bria M. Gorman, Nicholas R. Hum, Dina R. Weilhammer

This study uses single-cell RNA sequencing to analyze immune cell responses in the brain during VEEV infection, identifying distinct subpopulations and spatial patterns of immune infiltration.

Frontiers in Immunology · Dec 19, 2024Peer-reviewedImmunology

Spatiotemporal Analysis of Lung Immune Dynamics in Lethal Coccidioides posadasii Infection

Oscar A. Davalos, Aimy Sebastian, Nicole F. Leon, Margarita V. Rangel, Nadia Esmeralda Miranda, Deepa K. Murugesh, Ashlee M. Phillips, Katrina K. Hoyer, Nicholas R. Hum, Gabriela G. Loots, Dina R. Weilhammer

This study uses single-cell RNA sequencing and spatial transcriptomics to analyze lung immune responses during lethal Coccidioides infection, identifying macrophages and neutrophils involved in fibrosis and immune dysregulation.

mBio · Nov 29, 2024Peer-reviewedImmunology

Niche exclusion of a lung pathogen in mice with designed probiotic communities

Kelsey E Hern, Ashlee M Phillips, Catherine M Mageeney, Kelly P Williams, Anupama Sinha, Hans K Carlson, Kunal Poorey, Nicole M Collette, Steven S Branda, Adam P Arkin

This study shows that probiotic communities can prevent Burkholderia thailandensis infection in mice by reducing niche overlap with the pathogen.

bioRxiv · Feb 2, 2024Microbiology