Joseph S. Schoeniger

Temperature-Switchable Genome Editors from Extremophile-Derived Integrases

The paper identifies temperature-responsive integrases from extremophiles and demonstrates their use in creating temperature-switchable genome editing systems.

Mobile genetic elements are active and responsive to community context in model microbial consortium

The paper examines GI activity in a microbial consortium under stress, finding increased excision and expression compared to monocultures, and highlights the importance of community context in GI dynamics.

Intracellular screening of nanobodies reveals an intrabody that inhibits ITCH E3 ubiquitin ligase

The paper screens nanobodies to find an intrabody that inhibits ITCH E3 ubiquitin ligase activity in human cells using in vitro and intracellular assays.

HtPIP: High-Throughput Phage Isolation Platform increases diversity and reduces isolation time using multiple bacteria

The paper introduces HtPIP, a high-throughput phage isolation platform that increases diversity and reduces isolation time by isolating novel phages from environmental samples.

Integrase-On-Demand: Bioprospecting integrases for targeted genomic insertion of genetic cargo

The paper introduces Integrase-On-Demand (IOD), a method to identify integrases from bacteria and archaea that can integrate genetic cargo into target prokaryotes without requiring synthetic attB sites.

New candidates for regulated gene integrity revealed through precise mapping of integrative genetic elements

The paper introduces TIGER, a software tool that precisely maps integrative genetic elements, revealing 19 new cases of gene integrity regulation by IGEs.