KRAS-Mediated CCDC6 Degradation Drives xCT Upregulation and Ferroptosis Evasion
Daniela Criscuolo, Rosaria Catalano, Carmela Baviello, Claudia Fioravanti, Elena Vigliar, Francesco Morra, Maria Marotta, Junsei Mimura, Antonino Iaccarino, Francesco Pepe, Dorina Belotti, Giancarlo Troncone, Francesco Merolla, Rosa Marina Melillo, Angela Celetti
This study identifies a KRAS/CCDC6/xCT signaling axis that promotes ferroptosis resistance in KRAS-mutated cancers by inhibiting CCDC6 degradation, which enhances ATF4 activity and xCT expression.
APOPTOSIS · Jul 14, 2026Peer-reviewedCancer Biology