SON-mediated circular RNA suppression promotes PKR signaling and radiation resistance in glioblastoma
Caitlin A. Harvey, Sophia Dunlap, Mostafa Mohamed, Eshika Kudaravalli, Amr Elkholy, Leah Gehrs, Saeed Zaka Khosravi, Bohye Park, Kwang Wook Min, James M. Murphy, Opeyemi Iwaloye, Satoru Osuka, Ssang‐Taek Lim, Christopher Douglas Willey, Erik K. Flemington, Eun-Young Erin Ahn
This study identifies SON as a suppressor of circRNA biogenesis in glioblastoma, linking circRNA depletion to PKR signaling and radiation resistance.
bioRxiv · Sep 29, 2026 · PreprintCancer Biology