Cancer BiologybioRxivPreprint
Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer
Jun W. Kim, Christina M. Bebber, Yuqin Dai…·Julien Sage
The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.
DOI 10.64898/2026.03.27.714827