Brian J. Curtis

The paper reports chemoselective halogenation of Premarineosin A, yielding analogs with retained antiplasmodial activity against both sensitive and resistant Plasmodium falciparum strains.

This study uses metabolic engineering and late-stage functionalization to expand the chemical diversity of the antimalarial compound premarineosin A, identifying potent analogs.

The paper designs an engineered biosynthetic pathway in E. coli to produce (+)-brevianamides A and B, achieving a 46% yield with a 92:8 diastereomeric ratio.

This study identifies sex-specific metabolomic differences in C. elegans, revealing sex-dependent metabolites and their biological roles.