Muriel Koehl

Long-lived adult-born hippocampal neurons promote successful cognitive aging

The paper investigates how long-lived adult-born hippocampal neurons contribute to cognitive resilience in aging rats, showing their role in maintaining synaptic inputs and mitochondrial homeostasis.

CRITICAL ROLE OF ADULT-BORN DENTATE GRANULE NEURONS IN PATTERN COMPLETION

The paper shows adult-born dentate granule neurons contribute to pattern completion, a process critical for episodic memory, with implications for mental health disorders.

Vangl2, a core component of the WNT/PCP pathway, regulates adult hippocampal neurogenesis and age-related decline in cognitive flexibility

This study shows that Vangl2 regulates adult hippocampal neurogenesis and cognitive flexibility in mice, with reduced Vangl2 leading to impaired memory and increased interference-based forgetting.

Prenatal stress programs behavioral pattern separation in adult mice

This study shows that prenatal stress impairs pattern separation in adult mice, potentially contributing to cognitive deficits and behaviors similar to psychiatric disorders.

The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

Inhibition of mTOR signaling by genetic removal of p70 S6 Kinase 1 leads to anxiety-like disorders

This study shows that deleting S6K1 in adult mice causes anxiety-like behaviors and learning deficits, linked to reduced hippocampal neurogenesis and neuronal atrophy.