A-beta-induced distress of astrocytes triggers Alzheimer disease pathology through non-canonical delta secretase activity
Vanessa Schmidt, Ewelina Ziemlińska, Tomasz Obrębski, Ewa Żurawska-Płaksej, Jarosław Cendrowski, Barbara L. Hempstead, Thomas E. Willnow, Anna R. Malik
This study shows that impaired astrocyte stress response to amyloid-beta activates delta secretase, leading to amyloid and tau pathologies in Alzheimer's disease.
bioRxiv · Jan 30, 2025 · PreprintNeuroscience