Vanessa Schmidt

The paper shows sortilin mediates neuronal uptake of fatty acids via apoE, enabling their use as metabolic fuel, but this pathway is disrupted by apoE4, linked to Alzheimer's risk.

This study shows that impaired astrocyte stress response to amyloid-beta activates delta secretase, leading to amyloid and tau pathologies in Alzheimer's disease.

The paper shows SorLA restricts TNFα release from microglia, reducing their anti-tumor response and promoting glioma growth.

This study identifies SORCS2's role in pancreatic islet stress response, showing its importance in glucose-stimulated insulin release and metabolic health.

The paper introduces MeTaQuaC, an open-source R package for quality control in targeted metabolomics, improving data reliability through systematic error detection and visualization.