This study identifies LINC00941 as a KRAS-regulated lncRNA that promotes aggressiveness and chemoresistance in pancreatic cancer, with prognostic significance.

bioRxiv · Sep 29, 2025 · PreprintCancer Biology

Dual Specificity Phosphatase 3 knockdown drives myeloid leukemia cells to differentiate into macrophages and polarize

Jéssica Oliveira Farias, Diana R.D.C.G. Pacheco, Yuli Thamires Magalhães, Lilian C. Russo, Viktor Kalbermatter Boell, Donna Joe Farfan Hilares, Fábio Luís Forti

This study shows that DUSP3 knockdown promotes differentiation of myeloid leukemia cells into macrophages and alters their polarization markers.

Tissue and Cell · May 3, 2025Peer-reviewedImmunology

Temporal Analysis of Pituitary Transcriptional Dynamics in Mice Models of Hypopituitarism During Postnatal Development

Juliana Moreira Marques, Cláudia Veiga Chang, Nicholas Silvestre de Souza Trigueiro, Ricardo Vieira Araujo, Cinthya dos Santos Cerqueira, Lilian C. Russo, Bruna Azevedo, Berenice Bilharinho Mendonca, Nícolas C. Hoch, Luciani R. S. Carvalho

The paper analyzes pituitary transcriptional dynamics in mouse models of congenital hypopituitarism across developmental stages, revealing distinct gene expression patterns and functional impairments in Prop1 mutants.

bioRxiv · Feb 26, 2024 · PreprintDevelopmental Biology

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signalling

Lilian C. Russo, Rebeka Tomasin, Isaac de Araújo Matos, Antonio Carlos Manucci, Sven T. Sowa, Katie L. Dale, Keith W. Caldecott, L. Lehtiö, Deborah Schechtman, Flávia Carla Meotti, Alexandre Bruni‐Cardoso, Nícolas C. Hoch

This paper shows that the SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling in human cells.

Journal of Biological Chemistry · Aug 4, 2021Peer-reviewedMolecular Biology