ImmunologybioRxivPreprint
Rheumatoid Arthritis-associated IgG N-glycan agalactosylation diminishes neutrophilic inflammation by reducing FcgammaR binding and downstream signaling
Caroline Pumpe, Alfie Sanderson, Ballagh Forsyth…·Sonja Vermeren
This study shows that agalactosylated IgG N-glycans in RA reduce neutrophilic inflammation by decreasing FcγR binding and downstream signaling, suggesting they may act as a compensatory anti-inflammatory mechanism.
DOI 10.64898/2026.07.02.735866