Gordan Lauc

This study analyzes N-glycans in dried blood spots (DBS) from different blood preparations to distinguish pre-diabetes and diabetes, showing trends in fucosylation, bisection, galactosylation, and sialylation.

This study shows that agalactosylated IgG N-glycans in RA reduce neutrophilic inflammation by decreasing FcγR binding and downstream signaling, suggesting they may act as a compensatory anti-inflammatory mechanism.

This study uses AI to analyze blood molecular changes after MFAT or HA treatment in knee OA, showing MFAT alters systemic pathways more than HA.

This study identifies REG3β as a factor that removes aged neutrophils after myocardial infarction, promoting inflammation resolution and cardiac repair.

The paper reconstructs IgG-specific N-glycan profiles from total plasma N-glycome data, identifies known and novel loci associated with IgG N-glycosylation, and enables meta-analyses without new samples.

This study examines the evolutionary origins of glycosylation machinery genes and their targets in humans, revealing ancient and recent evolutionary patterns in the N-glycosylation pathway.

This study identifies 16 new genetic loci associated with plasma N-glycosylation in 10,000 individuals and links them to liver disease and inflammatory proteins.

This study compares N-glycosylation profiles of iPSCs and NSCs from DS and non-DS individuals, finding altered glycan structures in T21 cells during neural differentiation.

This study shows that disrupting BAP1, an epigenetic regulator, causes chromatin remodeling and leads to breast cancer stem cell-like properties and altered glycosylation.

The paper identifies a relationship between protein structure and glycan structure, introducing a glycoimpact matrix to predict glycosylation patterns and validate it through disease variants and engineered antibodies.

The paper identifies 16 genomic loci associated with IgG galactosylation through GWAS and validates three genes using CRISPR/dCas9 in an in vitro system.

The paper characterizes the evolution of the brain N-glycome across primates, finding increased complexity and human-specific sialic acid linkage changes.

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

The paper uses exome sequencing to identify rare variants in glycosyltransferase genes affecting transferrin and IgG glycosylation, linking them to disease-related traits.

The paper identifies genetic loci regulating glycosylation of transferrin and IgG, finding both shared and protein-specific associations and proposing tissue-specific transcription factor regulation.

This paper introduces a cutoff selection algorithm for correlation networks that uses prior knowledge to improve network reconstruction, showing better performance than statistical cutoffs across multiple datasets.

The paper evaluates normalization methods for glycomics data by assessing how well they enable accurate reconstruction of known glycosylation pathway reactions using Gaussian Graphical Models.

This study identifies twelve genetic loci associated with human blood plasma N-glycome composition through genome-wide association analysis, revealing both direct and indirect genetic influences on glycosylation.

This paper conducts a genome-wide meta-analysis of chronic back pain in 158,025 individuals, identifying three genetic loci associated with the condition.

The paper performs a GWAS on blood plasma proteome data from two cohorts to identify SNP-protein associations linked to various diseases and creates a genome-proteome network and web tool for analysis.