Rheumatoid Arthritis-associated IgG N-glycan agalactosylation diminishes neutrophilic inflammation by reducing FcgammaR binding and downstream signaling
Caroline Pumpe, Alfie Sanderson, Ballagh Forsyth, Jelena Šimunović, Yoshiki Narimatsu, H Clausen, Gordan Lauc, Mark Steven Cragg, Pierre Bruhns, Mohini Gray, C Bénézech, Caroline Hayward, Sonja Vermeren
This study shows that agalactosylated IgG N-glycans in RA reduce neutrophilic inflammation by decreasing FcγR binding and downstream signaling, suggesting they may act as a compensatory anti-inflammatory mechanism.
bioRxiv · Jul 7, 2026 · PreprintImmunology