Wolfgang Baumgärtner

Synergistic interference with SARS-CoV-2 replication by Molnupiravir-derived N4 hydroxycytidine and inhibitors of CTP synthetase

This paper shows that combining N4-hydroxycytidine with CTP synthetase inhibitors strongly reduces SARS-CoV-2 replication in cell culture and animal models.

Herpes Simplex Virus Assembly and Spread in murine skin after infection from the outside

This paper develops a novel murine ex vivo skin explant model to study HSV-1 infection and spread in intact skin, showing HSV-1 exclusively spreads in the epidermis through infected keratinocytes.

Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4'-fluorouridine

This paper shows that DHODH inhibitors enhance the antiviral effect of 4'-FlU against multiple RNA viruses, including influenza, SARS-CoV-2, and Ebola virus.

Region-specific spreading depolarization drives aberrant post-ictal behavior

This study identifies region-specific spreading depolarization as a key factor in post-ictal behavioral abnormalities in epilepsy using mouse and human data.

De-novo variants in XIRP1 associated with polydactyly and polysyndactyly in Holstein cattle

The paper identifies de-novo variants in XIRP1 associated with polydactyly and polysyndactyly in Holstein cattle through whole genome sequencing and bioinformatic analysis.

Use of Next Generation Sequencing to study two Cowpoxvirus outbreaks

This paper uses next-generation sequencing to analyze cowpox virus outbreaks in humans and cats, finding high clonality in a human outbreak and partial transmission in a feline outbreak.