This study investigates the role of CXCL12 in adipose tissue endothelial cells and finds it dispensable for adipose tissue function under normal and cold conditions, as well as during obesity.

bioRxiv · Oct 14, 2026 · PreprintPhysiology

Mathematical Modeling of the Canonical Aryl Hydrocarbon Receptor Pathway

Vincent Wieland, Tobias Blum, Irina Iriady, Laia Reverte-Salisa, Dilan Pathirana, Irmgard Foerster, Heike Weighardt, Jan Hasenauer

The paper develops a mathematical model of the canonical AhR pathway to identify which biochemical steps drive ligand-specific transcriptional responses using qPCR data from mouse macrophages.

bioRxiv · May 8, 2026 · PreprintSystems Biology

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

Frederike J. Graelmann, Fabian Gondorf, Yasmin Majlesain, Birte Niemann, Katarina Klepac, Dominic Gosejacob, Marlene Gottschalk, Michelle Mayer, Irina Iriady, Philip Hatzfeld, Sophie K. Lindenberg, Klaus Wunderling, Christoph Thiele, Zeinab Abdullah, Wei He, , Laia Reverte-Salisa

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

Molecular Metabolism · May 29, 2024Peer-reviewedImmunology