Christoph Thiele

This study shows that yolk sac-derived Kupffer cells regulate neonatal hepatocyte metabolism via Igf1 signaling, essential for glycogen storage and TCA cycle function.

This study identifies phosphatidylserine as an anti-inflammatory biomarker and shows that HDL-associated PS reduces atherosclerosis through plaque stabilization and immune modulation in mice.

This study shows that Sac1 regulates Golgi V-ATPase assembly by controlling TGN membrane composition through lipid exchange, leading to Golgi fragmentation and impaired glycosylation.

This study shows that primary cilia dysfunction in Bbs8-/- mice reduces adipose stem cells and promotes fibrogenic progenitors via disrupted Hedgehog signaling, affecting adipogenesis and lipid uptake.

The paper shows that mutations in the CerS homeodomain can either worsen or improve insulin resistance in Drosophila under high sugar diet conditions.

This study shows that peroxisomes interact with the Golgi in Drosophila insulin-producing cells to regulate sphingolipid composition and support insulin-like peptide secretion.

The paper proposes an experimental setup and computational framework to infer longitudinal single-cell lipid metabolism data from a single destructive measurement.

The paper shows that lipid imbalances in a Drosophila model of PME8 cause dendrite loss and that restoring specific ceramides while reducing bioactive lipids rescues the phenotype.

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

This study shows that ACC1 regulates adipose ILC2 differentiation and function in obesity, linking lipid metabolism to metabolic health.

This study shows that Creld2 is essential for maintaining liver metabolism homeostasis by linking the unfolded protein response (UPR) to metabolic regulation, with sex-specific effects in fatty liver disease.

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.