Alessandra Matzeu

Exploring sex differences in the prevention of ethanol drinking by naltrexone in dependent rats during abstinence

This study evaluates how naltrexone affects ethanol drinking in male and female rats during different stages of abstinence, finding sex-specific and time-dependent effects.

Knockdown of Hypocretin/Orexin Attenuates Extended-Access Cocaine Self-Administration in Rats

This study shows that knocking down hypocretin/orexin in rats reduces cocaine self-administration during extended access, suggesting a role in compulsive drug-taking behavior.

Dynorphin counteracts orexin in the paraventricular nucleus of the thalamus: cellular and behavioral evidence

This study shows that dynorphin in the paraventricular nucleus of the thalamus counteracts orexin's effect on cocaine-seeking behavior by reducing glutamate release.

Administration of orexin A in the posterior paraventricular nucleus of the thalamus promotes cocaine-seeking behavior and is associated with hypothalamic activation

The paper shows that orexin A injections in the posterior paraventricular nucleus of the thalamus (pPVT) reinstate cocaine-seeking behavior in rats after short abstinence but not after prolonged abstinence, with corresponding changes in hypothalamic neuronal activation.

Cebranopadol Blocks The Escalation Of Cocaine Intake And Conditioned Reinstatement Of Cocaine Seeking In Rats

Cebranopadol reduces cocaine intake escalation and reinstatement in rats but induces conditioned place preference.