A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD
Lynn J. A. Ebner, Cornelia Imsand, Duygu Karademir, Florian Peters, Eva Kiessling, Antonia Fottner, Claudia Matter, Diego S. Fajardo, Luca Merolla, Gabriele M Wögenstein, Ioanna Tsioti, Larissa P. Govers, Frank Blaser, Isabelle Meneau, Sanford L. Boye, , Marijana Samardzija
This paper develops a dual-acting RNAi therapy targeting Hif1a and Hif2a to protect retinal cells in AMD models, showing superior efficacy compared to single-target therapies.
Molecular Therapy · Sep 27, 2025Peer-reviewedNeuroscience