Author

Michael H. Lorenzini

Salk Institute for Biological StudiesORCID 0000-0002-7666-6584Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aaron J. Ho· 2 shared Graham McVickeriD· 2 shared Karthyayani Sajeev· 2 shared Shanna N. LavalleiD· 2 shared Aaron R. CheniD· 1 shared Ariana Fonseca· 1 shared Arko SeniD· 1 shared Brad BaldersoniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Aaron J. Ho

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2 papers

Recent·Most cited

Joint single-cell capture of Cas9 edits and transcriptomes reveals on- and off-target effects on gene expression

Michael H. Lorenzini, Brad Balderson, Shanna N. Lavalle, Karthyayani Sajeev, Aaron J. Ho, Madelyn Light, Olalekan H. Usman, Gavin Kurgan, Graham McVicker

Superb-seq captures single-cell Cas9 edits and transcriptomes, revealing on- and off-target effects on gene expression in over 34,000 cells.

bioRxiv · Feb 7, 2025 · PreprintGenomics

Deletion mapping of regulatory elements for GATA3 reveals a distal T helper 2 cell enhancer involved in allergic diseases

Hsiuyi V. Chen, Michael H. Lorenzini, Shanna N. Lavalle, Karthyayani Sajeev, Ariana Fonseca, Patrick C. Fiaux, Arko Sen, Ishika Luthra, Aaron J. Ho, Aaron R. Chen, Karthik Guruvayurappan, Carolyn O’Connor, Graham McVicker

The paper identifies a distal enhancer for GATA3 involved in allergic diseases by combining GWAS signals with deletion mapping in T helper 2 cells.

The American Journal of Human Genetics · Mar 28, 2023Peer-reviewedGenomics