Michel Olivier Steinmetz

The paper introduces susceptibility as a measure of how biomolecular condensates respond to solute perturbations, showing large variations in response across different condensates and solutes.

The paper identifies a low-affinity KDK motif in Kar9 that specializes +TIP body function by modulating microtubule dynamics through multivalent interactions with Bik1.

This study uses cryo-EM to resolve microtubule structures in different nucleotide states, revealing how GTP hydrolysis affects lattice stability and microtubule dynamics.

The paper introduces MiCSPARC, a cryo-EM pipeline for microtubule structure determination, achieving high-resolution reconstructions of decorated and undecorated microtubules.

This study shows taxanes induce conformational changes in microtubules, releasing GEF-H1 and activating RhoA signaling, leading to actin remodeling.

This study designs and tests PROTACs targeting β-tubulin, showing two compounds effectively degrade tubulin in cells.

This study investigates the phase separation of Bik1, a +TIP protein, revealing its conformational changes and fractal structure in liquid condensates.

The paper captures the release of a photopharmacological drug from tubulin using time-resolved serial crystallography and shows how ligand release triggers conformational changes.