Amin El Heliebi

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

The paper introduces SACCELERATOR, a framework for spatially aware clustering that improves benchmarking by incorporating expert feedback and consensus analysis across diverse datasets.

Inhibition of eukaryotic translation initiation factor 1A (eIF1A) and 3B (eIF3B) diminishes the psoriatic phenotype in two mouse models and human 3D model samples

The paper inhibits eIF1A and eIF3B in psoriasis models, reducing inflammation and restoring skin health in mice and human 3D models.

Tissue architecture and immune niches govern ctDNA release in colorectal cancer

This study identifies tissue architecture and immune niches as key factors influencing ctDNA release in colorectal cancer by integrating spatial transcriptomics and in situ mutation detection.

Circulating tumor cell characterization and classification by novel combinatorial dual-color (CoDuCo) in situ hybridization and supervised machine learning

The paper develops a novel CoDuCo in situ hybridization method combined with machine learning to classify and characterize circulating tumor cells in prostate cancer, identifying resistance mechanisms and therapeutic targets.

Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndrome

The paper identifies a disrupted trophoblast transition in preeclampsia, linking placental pathology to maternal syndrome through multi-omics profiling and in vitro analyses.