Laura M. Buchwald

Raw-count embeddings improve single-cell foundation models

This study benchmarks preprocessing strategies for single-cell transformer models and finds that simple log-transformed counts outperform complex methods, leading to a more efficient foundation model.

GephyrinΔ199-233 - an epileptogenic microdeletion

This study investigates a specific gephyrin microdeletion (Δ199-233) in a mouse model, showing disrupted synaptic function and neurological deficits linked to reduced inhibitory signal transmission.