Peter Kloppenburg

Redox-dependent synaptic clustering of gephyrin

This study shows that ROS-induced oxidation of gephyrin cysteines promotes synaptic multimerization and enhances inhibitory receptor clustering through disulfide bridges.

GephyrinΔ199-233 - an epileptogenic microdeletion

This study investigates a specific gephyrin microdeletion (Δ199-233) in a mouse model, showing disrupted synaptic function and neurological deficits linked to reduced inhibitory signal transmission.

Deficiency of Orexin Receptor Type 1 in Dopaminergic Neurons Increases Novelty-Induced Locomotion and Exploration

This study shows that deleting Ox1R in dopaminergic neurons increases novelty-induced locomotion and exploration without affecting other behaviors.

Development of a genetically-encoded sensor for probing endogenous nociceptin opioid peptide release

This paper develops a genetically encoded sensor, NOPLight, to detect endogenous N/OFQ release with high spatial and temporal resolution in vitro and in vivo.

Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca2+ channel activity in continuously active midbrain dopamine neurons

The paper shows that alternative splicing of β2-subunits stabilizes Cav2.3 Ca2+ channel activity in midbrain dopamine neurons, contributing to their vulnerability in Parkinson's disease.

Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

Task-specific roles of local interneurons for inter -and intraglomerular signaling in the insect antennal lobe

The paper investigates the role of spiking and nonspiking local interneurons in inter- and intraglomerular signaling in the cockroach antennal lobe using electrophysiology and calcium imaging.

Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach

This paper combines perforated patch-clamp recordings with the added buffer approach to accurately quantify neuronal Ca2+ handling properties, including both immobile and mobile buffers.

A Simple Method for Getting Standard Error on the Ratiometric Calcium Estimator

The paper introduces a simpler method to estimate standard errors for ratiometric calcium estimators by using uncertainty propagation and Monte-Carlo methods, avoiding complex protocols and background models.

Neuronal actin dynamics, spine density and neuronal dendritic complexity are regulated by CAP2

This study shows that CAP2 regulates neuronal actin dynamics, spine density, and dendritic complexity in mice by interacting with cofilin and affecting its phosphorylation.