Carolin Purmann

This study develops a 'Stress-in-a-dish' model using cortical organoids to investigate the molecular effects of cortisol on gene expression and potential PTSD-related mechanisms.

This paper develops a method to generate neuronal cells from adult fibroblasts and uses it to study gene expression and epigenetic changes in 22q11.2 deletion syndrome.

This study validates that heterozygous NRXN1 deletions impair neurotransmitter release in human neurons across multiple labs, suggesting a human-specific synaptic dysfunction relevant for schizophrenia drug discovery.

This study examines the transcriptome and epigenome effects of the 15q13.3 microdeletion in human induced neurons, identifying gene expression and pathway changes linked to neuropsychiatric disorders.

The paper investigates how large genomic deletions affect chromatin interactions and states in human brain development using Hi-C and ChIP-Seq analyses.