Yi‐Ling Huang

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry

This study uses single-cell whole genome amplification to link somatic mutations to cell identity and ancestry in a live donor.

Effect of cortisol on cortical organoids: Building a "stress in a dish" model system

This study develops a 'Stress-in-a-dish' model using cortical organoids to investigate the molecular effects of cortisol on gene expression and potential PTSD-related mechanisms.

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

Automatic detection of complex structural genome variation across world populations

The paper develops a method to detect complex structural variants across human genomes and finds they are associated with phenotypic hotspots and evolutionary changes.

Network effects of the neuropsychiatric 15q13.3 microdeletion on the transcriptome and epigenome in human induced neurons

This study examines the transcriptome and epigenome effects of the 15q13.3 microdeletion in human induced neurons, identifying gene expression and pathway changes linked to neuropsychiatric disorders.

Complete and haplotype-specific sequence assembly of segmental duplication-mediated genome rearrangements using CRISPR-targeted ultra-long read sequencing (CTLR-Seq)

The paper introduces CTLR-Seq, a method to resolve complex genomic regions with high accuracy, and applies it to study CNVs associated with schizophrenia and autism.

Genome-wide molecular effects of the neuropsychiatric 16p11 CNVs in an iPSC-to-iN neuronal model

The paper investigates the molecular effects of 16p11.2 CNVs on gene expression and DNA methylation using an iPSC-to-iN model and identifies potential contributing genes.

Haplotype-resolved and integrated genome analysis of the cancer cell line HepG2

This paper provides a haplotype-resolved genome analysis of the HepG2 cell line, identifying genomic features and allele-specific regulation to support functional genomics studies.

Extensive and deep sequencing of the Venter/HuRef genome for developing and benchmarking genome analysis tools

The paper generates deep re-sequencing datasets for the Venter/HuRef genome to develop and benchmark genome analysis tools using Illumina sequencing.