GenomicsbioRxivPreprint
Direct induction of human neurons from fibroblasts carrying the neuropsychiatric 22q11.2 microdeletion reveals transcriptome- and epigenome-wide alterations
Carolin Purmann, Cheen Euong Ang, Koji Tanabe…·Alexander Eckehart Urban
This paper develops a method to generate neuronal cells from adult fibroblasts and uses it to study gene expression and epigenetic changes in 22q11.2 deletion syndrome.