Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation
Daniel D. Lam, Rhîannan H. Williams, Ernesto Lujan, Koji Tanabe, Georg Huber, Nay Lui Saw, Juliane Merl‐Pham, Aaro V. Salminen, David Lohse, Sally Spendiff, Melanie J. Plastini, Michael Zech, Hanns Lochmüller, Arie Geerlof, Stefanie M. Hauck, , Juliane Winkelmann
This study identifies a synaptic mechanism linking collagen VI to motor control through cannabinoid receptor interaction and shows that CB1R agonists can improve motor performance in a dystonia mouse model.
Journal of Neuroscience · Dec 27, 2021Peer-reviewedNeuroscience